Overview The Cancer Prevention & Research Institute of Texas (CPRIT) provided $10.8 million grant to…
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors…
Oncolytic viruses selectively lyse tumor cells, disrupt immunosuppression within the tumor, and reactivate antitumor immunity,…
Intratumoral injection of oncolytic adenovirus Delta-24-RGDOX induces efficacious antiglioma immunity in syngeneic glioma mouse models.…
Background: Oncolytic adenoviruses are promising therapies for the treatment of gliomas. However, untargeted viral replication…
The eradication of brain tumor stem cells is essential for long-term brain tumor remission after…
Δ24-RGD is an infectivity-augmented, conditionally replicative oncolytic adenovirus with significant antiglioma effects. Although intratumoral delivery…
Emerging evidence suggests anti-cancer immunity is involved in the therapeutic effect induced by oncolytic viruses.…
Delta-24-RGD (DNX-2401) is a conditional replication-competent oncolytic virus engineered to preferentially replicate in and lyse…
